Pub. Date : 2014
PMID : 24971153
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lycopene Inhibits Urotensin-II-Induced Cardiomyocyte Hypertrophy in Neonatal Rat Cardiomyocytes. | Lycopene | urotensin 2 | Rattus norvegicus |
| 2 | This study investigated how lycopene affected urotensin-II- (U-II-) induced cardiomyocyte hypertrophy and the possible implicated mechanisms. | Lycopene | urotensin 2 | Rattus norvegicus |
| 3 | This study investigated how lycopene affected urotensin-II- (U-II-) induced cardiomyocyte hypertrophy and the possible implicated mechanisms. | Lycopene | urotensin 2 | Rattus norvegicus |
| 4 | The lycopene (3-10 mu M) pretreatment significantly inhibited the U-II-induced cardiomyocyte hypertrophy, decreased the production of U-II-induced reactive oxygen species (ROS), and reduced the level of NAD(P)H oxidase-4 expression. | Lycopene | urotensin 2 | Rattus norvegicus |
| 5 | The lycopene (3-10 mu M) pretreatment significantly inhibited the U-II-induced cardiomyocyte hypertrophy, decreased the production of U-II-induced reactive oxygen species (ROS), and reduced the level of NAD(P)H oxidase-4 expression. | Lycopene | urotensin 2 | Rattus norvegicus |
| 6 | Lycopene further inhibited the U-II-induced phosphorylation of the redox-sensitive extracellular signal-regulated kinases. | Lycopene | urotensin 2 | Rattus norvegicus |
| 7 | Moreover, lycopene treatment prevented the increase in the phosphorylation of serine-threonine kinase Akt and glycogen synthase kinase-3beta (GSK-3 beta ) caused by U-II without affecting the protein levels of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN). | Lycopene | urotensin 2 | Rattus norvegicus |
| 8 | These findings imply that lycopene yields antihypertrophic effects that can prevent the activation of the Akt/GSK-3 beta hypertrophic pathway by modulating PTEN inactivation through U-II treatment. | Lycopene | urotensin 2 | Rattus norvegicus |
| 9 | Thus, the data indicate that lycopene prevented U-II-induced cardiomyocyte hypertrophy through a mechanism involving the inhibition of redox signaling. | Lycopene | urotensin 2 | Rattus norvegicus |