Title : Involvement of glutathione peroxidase activity in the stimulation of 5-lipoxygenase activity by glutathione-depleting agents in human polymorphonuclear leukocytes.

Pub. Date : 1989 Apr 1

PMID : 2496978






1 Functional Relationships(s)
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1 Together with other experiments, it became obvious that the formation of leukotrienes, but also of 15-lipoxygenase products, requires a sharply defined threshold level of fatty acid hydroperoxides which are generated by the lipoxygenases and counteracted by glutathione-dependent peroxidase(s). Lipid Peroxides arachidonate 15-lipoxygenase Homo sapiens