Title : Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells.

Pub. Date : 2014

PMID : 24967384






3 Functional Relationships(s)
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Protein Name
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1 Our further studies demonstrated that ERR alpha suppressed ROS induction of tumor suppressor P53 and its target genes NOXA and XAF1 which are mediators of P53-dependent apoptosis. Reactive Oxygen Species tumor protein p53 Homo sapiens
2 Our further studies demonstrated that ERR alpha suppressed ROS induction of tumor suppressor P53 and its target genes NOXA and XAF1 which are mediators of P53-dependent apoptosis. Reactive Oxygen Species tumor protein p53 Homo sapiens
3 In conclusion, this study demonstrated that ERR alpha plays an important role in the development of MTX resistance through blocking MTX-induced ROS production and attenuating the activation of p53 mediated apoptosis signaling pathway, and points to ERR alpha as a novel target for improving osteosarcoma therapy. Reactive Oxygen Species tumor protein p53 Homo sapiens