Title : Rac1 regulates skin tumors by regulation of keratin 17 through recruitment and interaction with CD11b+Gr1+ cells.

Pub. Date : 2014 Jun 30

PMID : 24962779






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In a DMBA/TPA-induced mouse skin tumor model, inhibition of Rac1 activity and depletion of CD11b+Gr1+ cells resulted in significant tumor formation. Tetradecanoylphorbol Acetate integrin subunit alpha M Homo sapiens
2 TPA induced recruitment of CD11b+Gr1+ cells into dermis; however, Rac1 inhibitor abolished this recruitment. Tetradecanoylphorbol Acetate integrin subunit alpha M Homo sapiens