Pub. Date : 2014 Aug 15
PMID : 24959968
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2. | Disaccharides | fibroblast growth factor 2 | Homo sapiens |
| 2 | Herein, we evaluated the affinities of the same sugars against FGF2 and determined the crystal structures of FGF2 in complex with three disaccharides carrying N-sulfonated glucosamine and 2-O-sulfonated iduronic acid as basic backbones. | Disaccharides | fibroblast growth factor 2 | Homo sapiens |
| 3 | These findings suggest that the water-mediated interactions and the intermolecular interactions influence the binding affinity of different disaccharides with FGF2, correlating with their respective dissociation constants in solution. | Disaccharides | fibroblast growth factor 2 | Homo sapiens |