Title : All-trans retinoic acid enhances the effect of 5-aza-2'-deoxycytidine on p16INK4a demethylation, and the two drugs synergistically activate retinoic acid receptor β gene expression in the human erythroleukemia K562 cell line.

Pub. Date : 2014 Jul

PMID : 24959230






3 Functional Relationships(s)
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1 DAC in combination with ATRA appeared to produce a greater activation of the RAR-beta gene, which led to the upregulation of the RAR-beta expression level. Tretinoin retinoic acid receptor beta Homo sapiens
2 DAC in combination with ATRA appeared to produce a greater activation of the RAR-beta gene, which led to the upregulation of the RAR-beta expression level. Tretinoin retinoic acid receptor beta Homo sapiens
3 ATRA enhanced the effect of DAC on p16 demethylation, and the combination of the two drugs was found to activate RAR-beta expression, which indicated that DAC used in combination with ATRA has clinical potential in the treatment of human erythroleukemia. Tretinoin retinoic acid receptor beta Homo sapiens