Title : Hydrogen peroxide metabolism and sensing in human erythrocytes: a validated kinetic model and reappraisal of the role of peroxiredoxin II.

Pub. Date : 2014 Sep

PMID : 24952139






5 Functional Relationships(s)
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Protein Name
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1 The high rate constant (10(7)-10(8) M(-1) s(-1)) for H2O2 reduction determined for purified peroxiredoxin II (Prx2) and the high abundance of this protein indicate that under physiological conditions it consumes practically all the H2O2. Hydrogen Peroxide peroxiredoxin 2 Homo sapiens
2 The high rate constant (10(7)-10(8) M(-1) s(-1)) for H2O2 reduction determined for purified peroxiredoxin II (Prx2) and the high abundance of this protein indicate that under physiological conditions it consumes practically all the H2O2. Hydrogen Peroxide peroxiredoxin 2 Homo sapiens
3 However, this is inconsistent with extensive evidence that Prx2"s contribution to H2O2 elimination is comparable to that of catalase. Hydrogen Peroxide peroxiredoxin 2 Homo sapiens
4 Simulations of the responses to physiological H2O2 stimuli highlight that a design combining abundant Prx2 with a low effective peroxidase activity spares NADPH while improving potential signaling properties of the Prx2/thioredoxin/thioredoxin reductase system. Hydrogen Peroxide peroxiredoxin 2 Homo sapiens
5 Simulations of the responses to physiological H2O2 stimuli highlight that a design combining abundant Prx2 with a low effective peroxidase activity spares NADPH while improving potential signaling properties of the Prx2/thioredoxin/thioredoxin reductase system. Hydrogen Peroxide peroxiredoxin 2 Homo sapiens