Title : Design, synthesis and evaluation of highly selective pyridone-based class II MET inhibitors.

Pub. Date : 2014 Aug 1

PMID : 24951334






1 Functional Relationships(s)
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1 Integrated molecular docking and SAR studies resulted in the discovery of a novel class of pyridone MET inhibitors with high potency (IC50 of 0.005 muM) and efficient selectivity (>5000 fold) to VEGFR-2, c-Kit and RET kinases. Pyridones ret proto-oncogene Homo sapiens