Pub. Date : 2014 Jun
PMID : 24945799
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vvl and Kni bind to PG specific cis-regulatory elements that are required for expression of the ecdysone biosynthetic genes. | Ecdysone | ventral veins lacking | Drosophila melanogaster |
| 2 | Knock down of either vvl or kni in the PG results in a larval developmental arrest due to failure in ecdysone production. | Ecdysone | ventral veins lacking | Drosophila melanogaster |
| 3 | Furthermore, Vvl and Kni are also required for maintenance of TOR/S6K and prothoracicotropic hormone (PTTH) signaling in the PG, two major pathways that control ecdysone biosynthesis and PG cell growth. | Ecdysone | ventral veins lacking | Drosophila melanogaster |
| 4 | Our data show that Vvl and Kni directly regulate ecdysone biosynthesis by transcriptional control of biosynthetic gene expression and indirectly by affecting PTTH and TOR/S6K signaling. | Ecdysone | ventral veins lacking | Drosophila melanogaster |