Title : Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle.

Pub. Date : 2014 Aug 15

PMID : 24944202






1 Functional Relationships(s)
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1 The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors. Cyclic AMP interleukin 1 beta Mus musculus