Pub. Date : 2014 Jul 18
PMID : 24931672
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Knockdown of cAMP-response element binding protein (CREB) by siRNA blunted the up-regulation of PGC-1alpha and NRF-1 stimulated by 14,15-EET, and consequently abolished the neuroprotective effect of 14,15-EET. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cAMP responsive element binding protein 1 | Homo sapiens |
| 2 | Knockdown of cAMP-response element binding protein (CREB) by siRNA blunted the up-regulation of PGC-1alpha and NRF-1 stimulated by 14,15-EET, and consequently abolished the neuroprotective effect of 14,15-EET. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cAMP responsive element binding protein 1 | Homo sapiens |
| 3 | Knockdown of cAMP-response element binding protein (CREB) by siRNA blunted the up-regulation of PGC-1alpha and NRF-1 stimulated by 14,15-EET, and consequently abolished the neuroprotective effect of 14,15-EET. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cAMP responsive element binding protein 1 | Homo sapiens |
| 4 | Knockdown of cAMP-response element binding protein (CREB) by siRNA blunted the up-regulation of PGC-1alpha and NRF-1 stimulated by 14,15-EET, and consequently abolished the neuroprotective effect of 14,15-EET. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cAMP responsive element binding protein 1 | Homo sapiens |
| 5 | Our results indicate that 14,15-EET protects neurons from OGD-induced apoptosis by promoting mitochondrial biogenesis and function through CREB mediated activation of PGC-1alpha and NRF-1. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cAMP responsive element binding protein 1 | Homo sapiens |