Title : Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway.

Pub. Date : 2014 Jun 14

PMID : 24928142






3 Functional Relationships(s)
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1 Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway. Morphine mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Conversely, cyclooxygenase (COX)-2, primarily produced from peripheral macrophages in acute inflammation states, was up-regulated in the early phase at morphine-injected sites. Morphine mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 A morphine-induced shift in macrophage phenotype may be mediated by a COX-2-dependent mechanism. Morphine mitochondrially encoded cytochrome c oxidase II Homo sapiens