Title : Inhibition of pyruvate carboxylase by sequestration of coenzyme A with sodium benzoate.

Pub. Date : 1989 Feb 15

PMID : 2492793






3 Functional Relationships(s)
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1 Depletion of acetyl CoA was sufficient to account for greater than 50% reduction in pyruvate carboxylase activity. Acetyl Coenzyme A pyruvate carboxylase Homo sapiens
2 Competition between acetyl CoA and benzoyl CoA for the activator site on pyruvate carboxylase was insignificant. Acetyl Coenzyme A pyruvate carboxylase Homo sapiens
3 Results support the interpretation that the observed inhibition of pyruvate carboxylase occurred primarily by depletion of the activator, acetyl CoA, through sequestration of coenzyme A during benzoate metabolism. Acetyl Coenzyme A pyruvate carboxylase Homo sapiens