Title : Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells.

Pub. Date : 2014 Jul

PMID : 24924415






2 Functional Relationships(s)
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1 Additionally, treatment with the DNMT inhibitor, 5-aza-deoxycytidine (DAC), synergistically increased mRNA expression of aberrantly silenced genes important in breast cancer development, including PR, RARbeta, ERalpha, SFRP1, SFRP2, and E-cadherin in LSD2-KD cells. Decitabine secreted frizzled related protein 1 Homo sapiens
2 Additionally, treatment with the DNMT inhibitor, 5-aza-deoxycytidine (DAC), synergistically increased mRNA expression of aberrantly silenced genes important in breast cancer development, including PR, RARbeta, ERalpha, SFRP1, SFRP2, and E-cadherin in LSD2-KD cells. Decitabine secreted frizzled related protein 1 Homo sapiens