Title : Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependent oxidation of epicatechins.

Pub. Date : 2014 Sep 1

PMID : 24916123






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 MIF has an unusual N-terminal proline with catalytic activity, and targeting of this residue by small-molecule inhibitors has been shown to interfere with the biological activity of MIF. Proline macrophage migration inhibitory factor Homo sapiens
2 MIF has an unusual N-terminal proline with catalytic activity, and targeting of this residue by small-molecule inhibitors has been shown to interfere with the biological activity of MIF. Proline macrophage migration inhibitory factor Homo sapiens
3 We have characterized the modification introduced by oxidized (-)-epicatechin on MIF by LC-MS (liquid chromatography MS) and found it to occur at the N-terminal proline. Proline macrophage migration inhibitory factor Homo sapiens