Pub. Date : 2014
PMID : 24897122
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P-Glycoprotein has been proposed to hydrolyse ATP by an alternating mechanism, for which there is substantial experimental evidence, including inhibition of catalytic activity by trapping of ortho-vanadate at one nucleotide-binding domain, and the observation of an asymmetric occluded state. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | In this work, we have built several progressively more complex kinetic models, and then carried out simulations and detailed analysis, to test the validity of the proposed reaction pathway employed by P-glycoprotein for ATP hydrolysis. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | To establish kinetic parameters for the catalytic cycle, we made use of the large amount of published data on ATP hydrolysis by hamster P-glycoprotein, both purified and in membrane vesicles. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |