Title : Omega-3 PUFAs induce apoptosis of gastric cancer cells via ADORA1.

Pub. Date : 2014 Jun 1

PMID : 24896321






3 Functional Relationships(s)
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1 Moreover, we screened the expression profile of apoptosis-related genes in GC cells upon the treatment of DHA and/or EPA, and discovered that ADORA1, one subtype of adenosine receptor functionally involved in cell death, was up-regulated in response to DHA and EPA. Eicosapentaenoic Acid adenosine A1 receptor Homo sapiens
2 Moreover, we screened the expression profile of apoptosis-related genes in GC cells upon the treatment of DHA and/or EPA, and discovered that ADORA1, one subtype of adenosine receptor functionally involved in cell death, was up-regulated in response to DHA and EPA. Eicosapentaenoic Acid adenosine A1 receptor Homo sapiens
3 Importantly, when GC cells were treated with a selective ADORA1 antagonist, DPCPX, the DHA/EPA-induced apoptosis was substantially reduced. Eicosapentaenoic Acid adenosine A1 receptor Homo sapiens