Title : Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes.

Pub. Date : 2014 May 16

PMID : 24886859






1 Functional Relationships(s)
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1 Treatment with tranylcypromine and pargyline, which are potent inhibitors of LSD1, prevented IL-1beta-induced H3K9 demethylation at the mPGES-1 promoter and expression of mPGES-1. Pargyline lysine demethylase 1A Homo sapiens