Title : Valproate pretreatment protects pancreatic β-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3β.

Pub. Date : 2014 May 4

PMID : 24884462






1 Functional Relationships(s)
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1 However, valproate not only reduced the mRNA and protein expression of CHOP but also inhibited GSK-3beta and caspase-3 activity induced by palmitate, whereas, the mRNA expression of ATF4 was not affected. Valproic Acid caspase 3 Rattus norvegicus