Title : Methotrexate inhibits the viability of human melanoma cell lines and enhances Fas/Fas-ligand expression, apoptosis and response to interferon-alpha: rationale for its use in combination therapy.

Pub. Date : 2014 Dec 1

PMID : 24862567






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In cutaneous T-cell lymphoma (CTCL), MTX increases Fas death receptor by decreasing Fas promoter methylation by blocking the synthesis of SAM, the principal methyl donor for DNMTs, resulting in enhanced Fas-mediated apoptosis. Methotrexate TSPY like 2 Homo sapiens