Pub. Date : 2015 Apr 2
PMID : 24858040
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We identified the uric acid transporter SLC2A9 (also known as GLUT9) as a direct p53 target gene and a key downstream effector in the reduction of reactive oxygen species (ROS) through transporting uric acid as a source of antioxidant. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | We identified the uric acid transporter SLC2A9 (also known as GLUT9) as a direct p53 target gene and a key downstream effector in the reduction of reactive oxygen species (ROS) through transporting uric acid as a source of antioxidant. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | Oxidative stress induced SLC2A9 expression in a p53-dependent manner, and inhibition of SLC2A9 by small interfering RNA (siRNA) or anti-gout drugs such as probenecid significantly increased ROS levels in an uric acid-dependent manner and greatly sensitized cancer cells to chemotherapeutic drugs. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | The increased production of ROS because of p53 loss was rescued by SLC2A9 expression. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 5 | Our findings suggest that the p53-SLC2A9 pathway is a novel antioxidant mechanism that uses uric acid to maintain ROS homeostasis and prevent accumulation of ROS-associated damage that potentially contributes to cancer development. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 6 | Our findings suggest that the p53-SLC2A9 pathway is a novel antioxidant mechanism that uses uric acid to maintain ROS homeostasis and prevent accumulation of ROS-associated damage that potentially contributes to cancer development. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |