Title : Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine.

Pub. Date : 2014 Nov 15

PMID : 24853388






2 Functional Relationships(s)
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1 BACKGROUND: Subjective effects of cocaine are mediated primarily by dopamine (DA) transporter (DAT) blockade. Cocaine solute carrier family 6 member 3 Rattus norvegicus
2 Standard DUIs, which preferentially bind outward-facing DAT conformations, fully substituted for cocaine, consistently producing cocaine-like subjective effects at DA levels of 100-125% over basal values, regardless of dose or pretreatment time. Cocaine solute carrier family 6 member 3 Rattus norvegicus