Pub. Date : 2014 Apr
PMID : 24851101
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Nuclear Orphan Receptor NR4A1 is Involved in the Apoptotic Pathway Induced by LPS and Simvastatin in RAW 264.7 Macrophages. | Simvastatin | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 2 | Here, we show that the nuclear orphan receptor NR4A1 is involved in a caspase-independent apoptotic process induced by LPS and simvastatin. | Simvastatin | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 3 | Simvastatin-induced NR4A1 expression in RAW 264.7 macrophages and ectopic expression of a dominant-negative mutant form of NR4A1 effectively suppressed both DNA fragmentation and the disruption of mitochondrial membrane potential (MMP) during LPS- and simvastatin-induced apoptosis. | Simvastatin | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 4 | Simvastatin-induced NR4A1 expression in RAW 264.7 macrophages and ectopic expression of a dominant-negative mutant form of NR4A1 effectively suppressed both DNA fragmentation and the disruption of mitochondrial membrane potential (MMP) during LPS- and simvastatin-induced apoptosis. | Simvastatin | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 5 | Simvastatin-induced NR4A1 expression in RAW 264.7 macrophages and ectopic expression of a dominant-negative mutant form of NR4A1 effectively suppressed both DNA fragmentation and the disruption of mitochondrial membrane potential (MMP) during LPS- and simvastatin-induced apoptosis. | Simvastatin | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 6 | Our findings suggest that NR4A1 expression and mitochondrial translocation of Bax are related to simvastatin-induced apoptosis in LPS-activated RAW 264.7 macrophages. | Simvastatin | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |