Title : Lung injury after simulated cardiopulmonary bypass in an isolated perfused rat lung preparation: Role of mitogen-activated protein kinase/Akt signaling and the effects of theophylline.

Pub. Date : 2014 Nov

PMID : 24841445






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 p38-MAPK phosphorylation was not affected by theophylline; 0.083 mM theophylline inhibited reinflation-induced ERK1/2 phosphorylation (72%+-3%); and 3 mM theophylline inhibited Akt phosphorylation during deflation (75%+-5%) and reinflation (87%+-4%). Theophylline AKT serine/threonine kinase 1 Rattus norvegicus
2 p38-MAPK phosphorylation was not affected by theophylline; 0.083 mM theophylline inhibited reinflation-induced ERK1/2 phosphorylation (72%+-3%); and 3 mM theophylline inhibited Akt phosphorylation during deflation (75%+-5%) and reinflation (87%+-4%). Theophylline AKT serine/threonine kinase 1 Rattus norvegicus
3 A supratherapeutic theophylline dose protected lungs against deflation-induced injury and was associated with inhibition of phosphoinositide 3-kinase/Akt rather than phosphodiesterase. Theophylline AKT serine/threonine kinase 1 Rattus norvegicus