Title : Comparison of two endogenous biomarkers of CYP3A4 activity in a drug-drug interaction study between midostaurin and rifampicin.

Pub. Date : 2014 Aug

PMID : 24839948






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 CONCLUSIONS: Both 6betaCR and 4betaHC levels showed a good dynamic response range upon strong CYP3A4 induction with rifampicin. cholest-5-ene-3,4-diol cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Because of lower inter- and intrasubject variability, 4betaHC appeared more reliable and better predictive of CYP3A4 activity compared with 6betaCR. cholest-5-ene-3,4-diol cytochrome P450 family 3 subfamily A member 4 Homo sapiens