Pub. Date : 2014 Aug
PMID : 24836981
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We determined the role of ROS generation in mediating increases in IL-1beta secretion through caspase-1 activation caused by NLRP3 inflammasome activation in an environment-induced murine dry eye (DE) model. | Reactive Oxygen Species | interleukin 1 beta | Mus musculus |
| 2 | Increases in ROS production preceded rises in corneal and conjunctival gene expression of NLRP3 inflammasome components and IL-1beta that were identified using real-time PCR. | Reactive Oxygen Species | interleukin 1 beta | Mus musculus |
| 3 | Rises in ROS generation occurred after 1 week of ICES exposure, which preceded increases in gene expression of three NLRP3 inflammasome components (i.e. NLRP3, ASC and caspase-1) leading to rises in bioactive IL-1beta release. | Reactive Oxygen Species | interleukin 1 beta | Mus musculus |
| 4 | We show in a dessicating DE disease murine model that rises in ROS generation trigger NLRP3 inflammasome complexation and activation leading to increases in bioactive IL-1beta secretion. | Reactive Oxygen Species | interleukin 1 beta | Mus musculus |
| 5 | These results prompt us to suggest that the ROS-NLRP3-IL-1beta signaling pathway might play a priming role in environment-induced DE progression. | Reactive Oxygen Species | interleukin 1 beta | Mus musculus |