Title : Promyelocytic leukemia zinc finger-retinoic acid receptor α (PLZF-RARα), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes.

Pub. Date : 2014 Jul 4

PMID : 24821728






2 Functional Relationships(s)
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1 We found that PLZF-RARalpha can repress transcription of the p21WAF/CDKN1A gene, which encodes the negative cell cycle regulator p21 by binding to its proximal promoter Sp1-binding GC-boxes 3, 4, 5/6, a retinoic acid response element (RARE), and distal p53-responsive elements (p53REs). Tretinoin cyclin dependent kinase inhibitor 1A Homo sapiens
2 We found that PLZF-RARalpha can repress transcription of the p21WAF/CDKN1A gene, which encodes the negative cell cycle regulator p21 by binding to its proximal promoter Sp1-binding GC-boxes 3, 4, 5/6, a retinoic acid response element (RARE), and distal p53-responsive elements (p53REs). Tretinoin cyclin dependent kinase inhibitor 1A Homo sapiens