Title : An Asp49 phospholipase A2 from snake venom induces cyclooxygenase-2 expression and prostaglandin E2 production via activation of NF-κB, p38MAPK, and PKC in macrophages.

Pub. Date : 2014

PMID : 24808633






3 Functional Relationships(s)
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1 An Asp49 phospholipase A2 from snake venom induces cyclooxygenase-2 expression and prostaglandin E2 production via activation of NF-kappaB, p38MAPK, and PKC in macrophages. Dinoprostone nuclear factor kappa B subunit 1 Homo sapiens
2 By using NF-kappaB selective inhibitors, the involvement of this factor in MT-III-induced COX-2 expression and PGE2 production was demonstrated. Dinoprostone nuclear factor kappa B subunit 1 Homo sapiens
3 Altogether, these results show for the first time that the induction of COX-2 protein expression and PGE2 release, which occur via NF-kappaB activation induced by the sPLA2-MT-III in macrophages, are modulated by p38MAPK and PKC, but not by PI3K signaling proteins. Dinoprostone nuclear factor kappa B subunit 1 Homo sapiens