Title : An Asp49 phospholipase A2 from snake venom induces cyclooxygenase-2 expression and prostaglandin E2 production via activation of NF-κB, p38MAPK, and PKC in macrophages.

Pub. Date : 2014

PMID : 24808633






3 Functional Relationships(s)
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1 We previously demonstrated that a snake venom sPLA2 named MT-III leads to prostaglandin (PG)E2 biosynthesis in macrophages by inducing the expression of cyclooxygenase-2 (COX-2). Dinoprostone metallothionein 3 Homo sapiens
2 Moreover, MT-III-induced COX-2 protein expression and PGE2 release were attenuated by pretreatment of macrophages with SB202190, and Ly294002, and H-7-dihydro compounds, indicating the involvement of p38MAPK, PI3K, and PKC pathways, respectively. Dinoprostone metallothionein 3 Homo sapiens
3 Altogether, these results show for the first time that the induction of COX-2 protein expression and PGE2 release, which occur via NF-kappaB activation induced by the sPLA2-MT-III in macrophages, are modulated by p38MAPK and PKC, but not by PI3K signaling proteins. Dinoprostone metallothionein 3 Homo sapiens