Pub. Date : 2014 Aug
PMID : 24806638
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leucine facilitates the insulin-stimulated glucose uptake and insulin signaling in skeletal muscle cells: involving mTORC1 and mTORC2. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | The inhibitor of mammalian target of rapamycin complex 1 (mTORC1), rapamycin, had no effect on the insulin-stimulated glucose uptake, but eliminated the facilitating effect of leucine in the insulin-stimulated glucose uptake and AKT phosphorylation. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Together, these findings show that leucine can facilitate the insulin-induced insulin signaling and glucose uptake in skeletal muscle cells through both mTORC1 and mTORC2, implicating the potential importance of this amino acid in glucose homeostasis and providing new mechanistic insights. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |