Title : An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.

Pub. Date : 2014 May 7

PMID : 24806599






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 All tested haptens, but not irritants, can induce Syk activation, leading to both the CARD9/BCL10-dependent pro-IL-1 synthesis (signal1) and reactive oxygen species-mediated NLRP3 inflammasome activation (signal2), required for IL-1 secretion. Reactive Oxygen Species NLR family pyrin domain containing 3 Homo sapiens