Pub. Date : 2014 Jul
PMID : 24806432
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | To further explore the potential mechanism, we showed that curcumin increased the phosphorylation of ERK1/2 but not p38 MAPK in a time-dependent manner, and induced protein expression of the tumor suppressors FOXO3a and p53 in a dose-dependent manner, which were not observed in the presence of PD98059, an inhibitor of ERK1/2. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |
2 | To further explore the potential mechanism, we showed that curcumin increased the phosphorylation of ERK1/2 but not p38 MAPK in a time-dependent manner, and induced protein expression of the tumor suppressors FOXO3a and p53 in a dose-dependent manner, which were not observed in the presence of PD98059, an inhibitor of ERK1/2. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |
3 | Furthermore, blockade of ERK1/2 and exogenous expression of FOXO3a restored the effect of curcumin on growth of cells. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |
4 | Together, our studies show that curcumin inhibits growth and induces apoptosis of NPC cells through ERK1/2-mediated increase in the protein expression and interaction of p53 and FOXO3a. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |