Title : Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanism.

Pub. Date : 2014

PMID : 24805065






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1 This review summarizes our findings on the relative contribution of the heme-ligating moiety, side chains and the terminal group of ritonavir-like molecules to the ligand binding process, and highlights strategies for a structure-guided design of CYP3A4 inactivators. Heme cytochrome P450 family 3 subfamily A member 4 Homo sapiens