Title : COX-2 inhibitors arrest prostate cancer cell cycle progression by down-regulation of kinetochore/centromere proteins.

Pub. Date : 2014 Jul

PMID : 24802614






2 Functional Relationships(s)
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1 METHODS: Prostate cancer LNCaP, 22Rv1, and PC3 cells were cultured and treated with the COX-2 inhibitors celecoxib and CAY10404. Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 RESULTS: Treatment with the COX-2 inhibitors celecoxib and CAY10404 or knockdown of COX-2 significantly inhibited prostate cancer cell proliferation. Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens