Title : Regulation of p53-targeting microRNAs by polycyclic aromatic hydrocarbons: Implications in the etiology of multiple myeloma.

Pub. Date : 2015 Oct

PMID : 24798859






2 Functional Relationships(s)
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1 Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells. Benzo(a)pyrene tumor protein p53 Homo sapiens
2 Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells. Benzo(a)pyrene tumor protein p53 Homo sapiens