Title : Intracellular long-chain acyl CoAs activate TRPV1 channels.

Pub. Date : 2014

PMID : 24798548






5 Functional Relationships(s)
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1 The anionic phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is a known positive modulator of TRPV1 channels and the negatively charged phosphate groups interact with several basic amino acid residues in the proximal C-terminal TRP domain of the TRPV1 channel. Phosphatidylinositol 4,5-Diphosphate transient receptor potential cation channel subfamily V member 1 Homo sapiens
2 The anionic phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is a known positive modulator of TRPV1 channels and the negatively charged phosphate groups interact with several basic amino acid residues in the proximal C-terminal TRP domain of the TRPV1 channel. Phosphatidylinositol 4,5-Diphosphate transient receptor potential cation channel subfamily V member 1 Homo sapiens
3 The anionic phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is a known positive modulator of TRPV1 channels and the negatively charged phosphate groups interact with several basic amino acid residues in the proximal C-terminal TRP domain of the TRPV1 channel. Phosphatidylinositol 4,5-Diphosphate transient receptor potential cation channel subfamily V member 1 Homo sapiens
4 The anionic phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is a known positive modulator of TRPV1 channels and the negatively charged phosphate groups interact with several basic amino acid residues in the proximal C-terminal TRP domain of the TRPV1 channel. Phosphatidylinositol 4,5-Diphosphate transient receptor potential cation channel subfamily V member 1 Homo sapiens
5 Our results show that LC-CoAs are potent activators of the TRPV1 channel and interact with the same PIP2-binding residues in TRPV1. Phosphatidylinositol 4,5-Diphosphate transient receptor potential cation channel subfamily V member 1 Homo sapiens