Title : Strategy to enhance the therapeutic effect of doxorubicin in human hepatocellular carcinoma by selenocystine, a synergistic agent that regulates the ROS-mediated signaling.

Pub. Date : 2014 May 15

PMID : 24797310






1 Functional Relationships(s)
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1 Mechanistic studies indicated that this sensitization of SeC to DOX was achieved by triggering inactivation of ERK and AKT and DNA damage through reactive oxygen species (ROS) overproduction. Doxorubicin mitogen-activated protein kinase 1 Homo sapiens