Title : Transforming growth factor-β induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis.

Pub. Date : 2014 Sep

PMID : 24796928






3 Functional Relationships(s)
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1 In tumors, TGF-beta induces the metabolic conversion of glucose to lactate via glycolysis, a process referred to as the "Warburg effect." Lactic Acid transforming growth factor beta 1 Homo sapiens
2 RESULTS: Concentrations of lactate in peritoneal fluid paralleled those of TGF-beta1, being significantly higher in women with endometriosis compared to women without (P < .05). Lactic Acid transforming growth factor beta 1 Homo sapiens
3 Exposure of mesothelial cells to TGF-beta1 increased production of lactate (P < .05), increased HIF1A mRNA (P < .05), and protein, and increased concentrations of mRNAs encoded by glycolysis-associated genes (LDHA, PDK1, SLC2A1; P < .05). Lactic Acid transforming growth factor beta 1 Homo sapiens