Title : α5 Nicotinic acetylcholine receptor mediates nicotine-induced HIF-1α and VEGF expression in non-small cell lung cancer.

Pub. Date : 2014 Jul 15

PMID : 24793809






1 Functional Relationships(s)
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1 The silencing of alpha5-nAChR significantly inhibited the nicotine-induced cell proliferation compared with the control group and attenuated the nicotine-induced upregulation of HIF-1alpha and VEGF, and these effects required the cooperation of the ERK1/2 and PI3K/Akt signaling pathways. Nicotine mitogen-activated protein kinase 3 Homo sapiens