Title : Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes.

Pub. Date : 2014 Jul 1

PMID : 24792438






2 Functional Relationships(s)
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1 In those cells LPA was reported to induce IL-8 secretion through activation of various signaling pathways including p38 mitogen-activated protein kinase (p38 MAPK), p42/44 MAPK, and Rho kinase. lysophosphatidic acid mitogen-activated protein kinase 3 Homo sapiens
2 In addition to those pathways we report that mitogen- and stress-activated protein kinases (MSKs) known to be activated downstream of the ERK1/2 and p38 MAPK cascades and CREB are phosphorylated in response to LPA. lysophosphatidic acid mitogen-activated protein kinase 3 Homo sapiens