Title : The heparin and pentosan polysulfate binding sites of human antithrombin overlap but are not identical.

Pub. Date : 1989 Oct 20

PMID : 2478364






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The heparin and pentosan polysulfate binding sites of human antithrombin overlap but are not identical. Pentosan Sulfuric Polyester serpin family C member 1 Homo sapiens
2 On the other hand, pentosan polysulfate protects only Lys-125 and causes no appreciable conformational change, although it is also capable of enhancing the antithrombin-thrombin interaction. Pentosan Sulfuric Polyester serpin family C member 1 Homo sapiens
3 These data clearly demonstrate that the heparin and pentosan polysulfate binding sites of antithrombin overlap (at Lys-125) but are not identical. Pentosan Sulfuric Polyester serpin family C member 1 Homo sapiens