Title : Regulation of Gβγi-dependent PLC-β3 activity in smooth muscle: inhibitory phosphorylation of PLC-β3 by PKA and PKG and stimulatory phosphorylation of Gαi-GTPase-activating protein RGS2 by PKG.

Pub. Date : 2014 Nov

PMID : 24777815






1 Functional Relationships(s)
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1 In gastrointestinal smooth muscle, agonists that bind to Gi-coupled receptors activate preferentially PLC-beta3 via Gbetagamma to stimulate phosphoinositide (PI) hydrolysis and generate inositol 1,4,5-trisphosphate (IP3) leading to IP3-dependent Ca(2+) release and muscle contraction. gbetagamma phospholipase C beta 3 Homo sapiens