Title : Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.

Pub. Date : 2014 May 22

PMID : 24773054






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Compound 28 inhibited the photolabeling of P-gp with [(125)I]-iodoarylazidoprazosin with IC50 = 0.75 muM and stimulated the basal ATP hydrolysis of P-gp in a concentration-dependent manner (EC50 ATPase = 0.027 muM). Adenosine Triphosphate ATP binding cassette subfamily B member 1 Homo sapiens