Title : Expression of ribonucleoside reductase subunit M1, but not excision repair cross-complementation group 1, is predictive in muscle-invasive bladder cancer treated with chemotherapy and radiation.

Pub. Date : 2014 May

PMID : 24772321






2 Functional Relationships(s)
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Protein Name
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1 RRM1 expression predicted an improved CR in patients treated with gemcitabine-based chemoradiotherapy (57 vs. 100%, P=0.036), but not in those treated with other agents (56 vs. 88%, P=0.29). gemcitabine ribonucleotide reductase catalytic subunit M1 Homo sapiens
2 In the univariate analysis, RRM1 expression, but not ERCC1 expression, was identified as a prognostic marker for worse cancer-specific survival in all the patients and in those treated with gemcitabine-based regimens. gemcitabine ribonucleotide reductase catalytic subunit M1 Homo sapiens