Pub. Date : 2014 Jun 1
PMID : 24771855
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We hypothesize that the LTA4H aminopeptidase activity alleviates neutrophilic inflammation, which contributes to cigarette smoke (CS)-induced emphysema by clearing proline-glycine-proline (PGP), a triamino acid chemokine known to induce chemotaxis of neutrophils. | pgp | leukotriene A4 hydrolase | Mus musculus |
| 2 | This resulted in accumulation of PGP in the airspaces by suppressing the LTA4H aminopeptidase activity. | pgp | leukotriene A4 hydrolase | Mus musculus |
| 3 | When the LTA4H aminopeptidase activity was selectively augmented by 4MDM, the levels of PGP in the bronchoalveolar lavage fluid and infiltration of neutrophils into the lungs were significantly reduced without affecting the levels of leukotriene B4. | pgp | leukotriene A4 hydrolase | Mus musculus |