Pub. Date : 2014 May 15
PMID : 24770864
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We next identified fisetin as an inhibitor of YB-1 activation. | fisetin | Y-box binding protein 1 | Homo sapiens |
| 2 | Computational docking and molecular dynamics suggested that fisetin binds on the residues from beta1 - beta4 strands of CSD, hindering Akt"s interaction with YB-1. | fisetin | Y-box binding protein 1 | Homo sapiens |
| 3 | Fisetin also inhibited EGF induced YB-1 phosphorylation and markers of EMT both in vitro and in vivo. | fisetin | Y-box binding protein 1 | Homo sapiens |
| 4 | Collectively our data suggest that YB-1 induces EMT in PCa and identify fisetin as an inhibitor of its activation. | fisetin | Y-box binding protein 1 | Homo sapiens |