Pub. Date : 2014 Nov
PMID : 24770794
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fewer fluctuations, higher maximum concentration and better motor response of levodopa with catechol-O-methyltransferase inhibition. | Levodopa | catechol-O-methyltransferase | Homo sapiens |
| 2 | Catechol-O-methyltransferase inhibitor addition to levodopa/carbidopa formulations improves motor symptoms and reduces levodopa fluctuations in patients with Parkinson"s disease. | Levodopa | catechol-O-methyltransferase | Homo sapiens |
| 3 | Catechol-O-methyltransferase inhibitor addition to levodopa/carbidopa formulations improves motor symptoms and reduces levodopa fluctuations in patients with Parkinson"s disease. | Levodopa | catechol-O-methyltransferase | Homo sapiens |
| 4 | Catechol-O-methyltransferase inhibition caused less fluctuations and higher baseline levels of levodopa after the first intake and less 3-O-methyldopa appearance. | Levodopa | catechol-O-methyltransferase | Homo sapiens |
| 5 | The maximum levodopa concentrations were higher after the second levodopa intake, particularly with catechol-O-methyltransferase inhibition. | Levodopa | catechol-O-methyltransferase | Homo sapiens |
| 6 | The maximum levodopa concentrations were higher after the second levodopa intake, particularly with catechol-O-methyltransferase inhibition. | Levodopa | catechol-O-methyltransferase | Homo sapiens |
| 7 | The motor response to levodopa was better with catechol-O-methyltransferase inhibition than without, tolcapone was superior to entacapone. | Levodopa | catechol-O-methyltransferase | Homo sapiens |
| 8 | More continuous levodopa brain delivery and lower 3-O-methyldopa bioavailability caused a better motor response during catechol-O-methyltransferase inhibition. | Levodopa | catechol-O-methyltransferase | Homo sapiens |