Title : Short-term effects of extended-release niacin with and without the addition of laropiprant on endothelial function in individuals with low HDL-C: a randomized, controlled crossover trial.

Pub. Date : 2014 Jun 1

PMID : 24768191






1 Functional Relationships(s)
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Protein Name
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1 Niacin directly activates both GPR-109A in leukocytes and the heme oxygenase-1 pathway, promoting strong anti-inflammatory and antioxidative effects, as well as induces immediate production of prostaglandin D2, leading to endothelial vasodilation. Niacin hydroxycarboxylic acid receptor 2 Homo sapiens