Title : ACTH as a treatment for acute crystal-induced arthritis: update on clinical evidence and mechanisms of action.

Pub. Date : 2014 Apr

PMID : 24762710






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1 The mechanism of action of ACTH in acute crystal-induced arthritis is not entirely known but seems to extend beyond stimulation of steroid release from the adrenal glands; ACTH is able to stimulate melanocortin receptors on macrophages and downregulate gouty inflammation. Steroids proopiomelanocortin Homo sapiens