Title : Monoterpene glycoside ESK246 from Pittosporum targets LAT3 amino acid transport and prostate cancer cell growth.

Pub. Date : 2014 Jun 20

PMID : 24762008






2 Functional Relationships(s)
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1 Leucine is not only important as a building block for proteins, but plays a critical role in mTORC1 signaling leading to protein translation. Leucine CREB regulated transcription coactivator 1 Mus musculus
2 We further show in LNCaP prostate cancer cells that ESK246 is a potent (IC50 = 8.12 muM) inhibitor of leucine uptake, leading to reduced mTORC1 signaling, cell cycle protein expression and cell proliferation. Leucine CREB regulated transcription coactivator 1 Mus musculus